b cell receptor造句

• Research is also investigating therapies targeting B cell receptor signalling.
• CD22 functions as an inhibitory receptor for B cell receptor ( BCR ) signaling.
• Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation.
• This process of changing the specificity of the immature B cell receptor is called receptor editing.
• In 2015, it was reported that 226 companies are working on B cell receptor signalling pathways.
• In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation.
• These cells have receptors that are similar to B cell receptors, and each cell recognizes only a few class II-peptide combinations.
• Weakly autoreactive B cells may also remain in a state of immunological ignorance where they simply do not respond to stimulation of their B cell receptor.
• Like the T cell, B cells express a unique B cell receptor ( BCR ), in this case, a membrane-bound antibody molecule.
• Class switching only occurs after the B cell binds an antigen through its B cell receptor, and is activated through interaction with a T helper cell.
• These studies indicate preexisting subset differences in B cell receptor ( BCR ) specificity and antigen-driven B cell fate that remain important unresolved features of the system.
• Based upon the pre-B cell receptor ( pre-BCR ), Surrobodies are non-naturally occurring, antibody like proteins with high affinity to their antigen.
• Once a T cell recognizes a peptide within an MHC class II molecule, it can stimulate B-cells that also recognize the same molecule in their B cell receptors.
• The Garcia Laboratory reported the structure of the pre-B cell receptor ( pre-BCR ) in 2007, which revealed how pre-BCRs oligomerize to signal in the absence of antigen.
• Deletion of the N-terminal part of the heavy chain disease protein leads to aggregation and signaling of the B cell receptor, presumably due to the loss of the anti-aggregating properties of the light chain.
• The occurrence of CD79A thus coincides with the evolution of B cell receptors with greater diversity generated by recombination of multiple V, D, and J elements in bony fish contrasting the single V, D and J elements found in shark.
• In malignant B cells miRNAs participate in pathways fundamental to B cell development like B cell receptor ( BCR ) signalling, B cell migration / adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins.
• Somatic hypermutation, thus, makes the B cell receptors and the soluble antibodies in subsequent encounters with antigens, more inclusive in their antigen recognition potential of " altered " epitopes, apart from bestowing greater specificity for the antigen that induced proliferation in the first place.
• On the surface of early preB cells, CD179a / CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a / CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor ( preBCR ).
• This enzyme participates in 14 metabolic pathways : erbb signaling pathway, cell cycle, wnt signaling pathway, hedgehog signaling pathway, axon guidance, focal adhesion, b cell receptor signaling pathway, insulin signaling pathway, melanogenesis, alzheimer's disease, colorectal cancer, endometrial cancer, prostate cancer, and basal cell carcinoma.